Publicaciones Científicas

Del Dr PhD Fernando Abarz√ļa en distintas revistas especializadas del mundo.

Combination chemotherapy with estramustine phosphate ifosfamide and cisplatin for homone refractory prostate cancer.                                                  

Adenovirus-Mediated Overexpression of REIC-Dkk-3 Selectively Induces Apoptosis in Human Prostate Cancer Cells through Activation of c-Jun-NH2-Kinase

The Dickkopf (Dkk) gene family is suggested to prevent Wnt
signaling, leading to suppression of pleiotropic effects in critical
biological contexts including development.

REIC/Dickkopf-3 (Dkk-3), a tumor suppressor gene, has been¬†investigated in gene therapy studies.Our previous study¬†suggested that REIC/Dkk-3‚Äďinduced apoptosis mainly.

We had previously reported that REIC/Dkk-3, a member of the Dickkopf (Dkk) gene family, works as a tumor suppressor. In this study, we evaluated the therapeutic effects of an intratumoral injection.

Overexpression of REIC/Dkk-3  induces cancer cell apoptosis through endoplasmic reticulum stress. Therefore, the identification of the portion of REIC/Dkk-3 that causes
ER stress.

An N-terminal 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis
Fernando Abarzua, Yuji Kashiwakura, Munenori Takaoka, Masami Watanabe, Kazuhiko Ochiai, Masakiyo Sakaguchi.

Recently showed that overexpression of REIC/ Dickkopf-3, a tumor suppressor gene, induced apoptosis in a tumor cell-specific manner. The aim of the
present study was to determine the mechanisms.

Annals of Oncology Advance Access published: Hepatocyte growth factor activator inibitor-2(HAI-2) is a favorable prognosis marker and inhibits cell growth through the apoptotic pathway in cervical cancer

Abstract. In light of the poor prognosis for ovarian cancer patients, the research continues for innovative and efficacious
treatment modalities. Along with surgical and chemotherapeutic.

(UUT-UC) represents 5- 6% of all urothelial carcinomas. Macroscopic hematuria is
the most common symptom. In addition, a complementary retrograde teropyelography with collecting selective urinary.

Heat shock proteins play a crucial role in tumor-specific apoptosis by REIC/Dkk-3.  The aim of the
present study was to determine the mechanisms underlying
the selective induction of apoptosis

This studywas undertaken to reveal the trends of prostate cancer and the outcome of treatment modalities for each diseas estage in patients in a single institute over a 10-year period. 

Radical cystectomy with urinary tract reconstruction currently remains the standard treatment for invasive bladder cancer. During the last decade orthotopic urinary reservoirs (OUR) have
become a gold standard.

Human testicular cancer is very sensitive to
chemotherapy and radiation therapy and is regarded as a curable cancer. The cancer prevails in the young reproductive generation.

The field of ureteroscopy has expanded greatly during the last 2 decades, in step with the increasing miniaturization of instruments, the advancement of optical and manipulation designs.